Veronica EGGER A novel hypothesis on the role of olfactory bulb granule cells
invitée par Boris BARBOUR - Section Neurosciences
11h à 12h30
Le séminaire de Veronica EGGER (University of Regensburg, Allemagne) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris
The role of granule cells in olfactory processing is surrounded by several enigmatic observations, such as the purpose of reciprocal spines and the mechanisms for GABA releases, the missing proof for functional reciprocal connectivity, and the apparently negligible contribution of granule cells to both recurrent and lateral inhibition. I summarize recent results with regard to mechanisms of GABA release and outline a novel hypothesis that has the potential to resolve most of these enigmas and allows further predictions on the function of granule cells in odor processing, ultimately explaining the unusual microcircuit of the granule cell reciprocal spine as a means of olfactory combinatorial coding.