Stéphane LE CROM
Asistant Professor (École Normale Supérieure)

I am currently doing my research in the Molecular Biology of Development laboratory (INSERM U368) on gene expression analysis during nervous system development using DNA microarrays. I am equally responsible for bioinformatic on the ENS transcriptome plateform. For the teaching part, I am equally responsible for the ENS bachelor degree in Biology and I am teaching in some of the modules of the ENS Biology Master degree.

You can reach me by e-mail or you can visit my personal web site for further informations on my experiences (publications details, scientifc communications, teaching, ...).

Une version française de cette page est disponible ici.

Curriculum Vitae

EDUCATION:

1997-2000: Ph. D. at the University Parix XI (Orsay) with research activity at the CNRS (Gif-sur-Yvette)
1997: Graduate Degree (Magistère) from the Ecole Normale Supérieure (Lyon)
Specialization in Cellular and Molecular Biology

SCIENTIFIC EXPERIENCE:

From 2003: Molecular Biology of Development (Ecole Normale Supérieure, Paris)
Post-Doctoral Position Dr Patrick CHARNAY Laboratory
Title: Gene regulation networks analyses during nervous system development
2002:
(1 year)		 Biochimie Department (Université de Montréal, Montréal, Canada)
Post-Doctoral Position Dr Stephen MICHNICK Laboratory
Title: A strategy to decipher integrate maps of biochemical regulation network in living cells
2001-2002:
(6 months)		 Molecular Biology of Development (Ecole Normale Supérieure, Paris)
Post-Doctoral Position Dr Patrick CHARNAY Laboratory
Title: Tools development for the analysis of Krox-20 regulated genes using microarrays
2000-2001:
(10 months)

Molecular Genetic Laboratory (Ecole Normale Supérieure, Paris)
Post-Doctoral Position Pr Claude JACQ Laboratory
Title: Target analysis of multi-drug resistant transcription factor in yeast using microarrays
1997-2000:
(3 years)
Ph.D. 		Alfred Fessard Institute of Neurobiology (CNRS, Gif-sur-Yvette, France)
Ph. D. Dr Philippe VERNIER Laboratory
Title: Compared analysis of D1 dopamine receptors in vertebrates: Definition of functional property discriminant of each D1 receptor subtypes
1996-1997:
(9 months)		 Alfred Fessard Institute (CNRS, Gif-sur-Yvette, France)
Graduate’s degree Dr Philippe VERNIER Laboratory
Title: Desensitization: a functional homologous criteria for the dopamine D1 receptor subtypes in vertebrates

AWARDS:

2002: Post-doctoral fellowship from the “International Agency for Research on Cancer” (World Health Organization)
2002: Post-doctoral fellowship from the French “Ligue contre le Cancer”
2000: Grant from the French “Fondation pour la Recherche Médicale”
1999 July: Grant to participate to the "Gordon Research Conference on Catecholamines" at Oxford (Great-Britain)
1998-2000: Grant from the French “Ministère de la Recherche et de l'Enseignement Supérieur”
1993: Admission, by competitive examination, to the Ecole Normale Supérieure de Lyon

PUBLICATIONS LIST:

Published Papers
  Lelandais G., S. Le Crom, F. Devaux, Vialette S., Church G.M., C. Jacq et P. Marc (2004). yMGV: a cross-species expression data mining tool. Nucleic Acid Research 32(Database issue): D323-D325.
  Palková Z., F. Devaux , _i_icová., L. Mináriková, S. Le Crom and C. Jacq (2002). Ammonia pulses and metabolic oscillations guide yeast colony development. Molecular Biology of the Cell 13(11): 3901-3914.
  Le Crom S., D. Prou et P. Vernier (2002). Autocrine adenosine receptor activation blocks D1A but not D1B dopamine receptor desensitization. Journal of Neurochemistry 82(6): 1549-1552.
  Le Crom S., F. Devaux, P. Marc, X. Zhang, W.S. Moye-Rowley et C. Jacq (2002). New insights into the PDR network from genome-wide characterization of the YRR1 transcription factor regulation system. Molecular and Cellular Biology 22(8): 2642-2649.
  Le Crom S., F. Devaux, C. Jacq et P. Marc (2002). yMGV: helping biologists for yeast microarray data mining. Nucleic Acid Research 30(1): 76-79.
  Prou D., W-J. Gu, D. Prou, S. Le Crom, S. Maltais, J-D. Vincent, J. Salamero et P. Vernier (2001). Intracellular retention of the two isoforms of the D2 dopamine receptor promotes endoplasmic reticulum disruption. Journal of Cell Science 114: 3517-3527.
  Le Crom S. et H. Donner (2001). Analysis comparison of regulatory properties of the yeast transcription factor YRR1 using both cDNA microarrays and MWG's Pan® Yeast Array. MWG Application Note (June 2001).
  Gines S., J. Hillion, M. Torvinen, S. Le Crom, V. Casado, EI. Canela, S. Rondin, JY. Lew, S. Watson, M. Zoli, LF Agnati, P. Vernier, C. Lluis, S. Ferre, K. Fuxe et R. Franco (2000). Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proceedings of the National Academy of Sciences of the United States of America 97 (15): 8606-8611.

Reviews
  Callier S, Snapyan M, Le Crom S, Prou D, Vincent JD et Vernier P (2003). Evolution and cell biology of dopamine receptors in vertebrates. Biology of the Cell 95(7): 489-502.
  Le Crom S., M. Kapsimali, P-O. Barôme et P. Vernier (2002). Dopamine receptors for every species : Gene duplications and functional diversification in Craniates. Journal of Structural and Functional Genomics 3(1-4): 161-176.
  Le Crom S., M. Kapsimali, J-D. Vincent et P. Vernier (2000). L'émotion en héritage: une histoire de dopamine? Découverte (Revue du Palais de la Découverte). 282 (novembre): 74-85.
  Kapsimali M., H. Dumond, S. Le Crom, S. Coudouel, J-D. Vincent et P. Vernier (2000). Evolution et développement des systèmes neuromodulateurs dopaminergiques chez les vertébrés. Journal de la Société de Biologie 194 (2): 87-93.

Book Chapters
  Kapsimali M., S. Le Crom et P. Vernier (2002). A natural history of vertebrate dopamine receptors (sous presse dans Dopamine Receptors and Transporters Second edition. Edited by A. Sidhu, P. Vernier and M. Laruelle. New York: Marcel Dekker, Inc).