Presentation
Inhibitory neurons play an important role in the functional architecture of brain microcircuits. Fast inhibition mediated by ligand-gated chloride channels controls the gain and shapes the temporal output of neuronal assemblies. In the vertebrate hindbrain, inhibitory transmission is mediated by glycine and GABA, which can be released by separate neurons or co-released by mixed inhibitory neurons, thus creating a complex interplay between these transmitter systems. We study the physiology of inhibitory neurons at the molecular, synaptic and network levels, with a special emphasis on the relationship between glycinergic and GABAergic transmission.
Last update : 12 November 2008
