TRANSCRIPTOMES, TRANSCRIPTION ACTIVATORS AND MICROARRAYS
F. Devaux*,
P.
Marc*,C. Jacq
* Both authors contributed equally to this work
FEBS letters, 498(2-3):140-4 (june 2001)
Abstract:
Gene-specific transcription activators are among the main factors which
specifically shape the transcriptome profiles. It is tempting to take advantage
of their properties to decipher the genome expression circuitry. The advent
of microarray technology has offered fantastic opportunities to quickly
analyse the expression profiles dictated by specific transcription factors.
This review will first focus on the strategies which have been devised
to control the activity of transcription factors and in the second part
on the microarray experiments which addressed the role of these transcription
factors in the genome-wide expression profile. This last part will mainly
consider the case of the yeast Saccharomyces cerevisiae genome. All the
collected data are available through the on-line database yTAFNET (http://transcriptome.ens.fr/ytafnet/).
yTAFNET is designed to help the characterization of connections between
the different yeast regulatory networks.
Last updated august 20th 2001 by MARC
Philippe