Web supplement to 2002 NAR database issue:
yMGV: helping biologists for yeast microarray data mining
Le Crom S., Devaux F., Jacq C. and Marc P.

Comparing expression regulation of two genes across all published experiments

We compared the transcription profiles of PDR1 with those of its functional and structural homologue PDR3. These two genes behave roughly the same way, and only a few number of discriminating profiles can be observed. Among them, both inactivation of the Swi1p and Snf2p transcriptional regulators (Sudarsanam et al., 2000) led to a 4 fold increase of PDR3 expression, with no significant modification of PDR1 expression level.

PDR1	PDR3
Original diagram drawing after yMGV query for PDR1	Original diagram drawing after yMGV query for PDR3
Figure 2B from the publication	Figure 2C from the publication
The “alignment transcription profile for several genes” was used to query yMGV for PDR1 and PDR3 genes. The main different results obtain are represented on this figure. Induction of PDR1 and PDR3 genes when the member of the Swi/Snf system are deleted whatever the growth conditions are, rich (YPG) or poor (WO) glucose medium (Sudarsanam et al., 2000).

In normal conditions, Pdr1p is the most abundant regulator of the PDR network whereas Pdr3p is poorly expressed. PDR3 transcription has been shown previously to be specifically activated in cells that lacks the mitochondrial genome (Hallstrom et al., 2000). To date the regulators responsible for this activation are completely unknown. The above observation suggests that SWI1 and SNF2 are involved in the control of PDR3 expression.