The DNA binding pattern of Pdr1p in the presence and absence of fluphenazine was analyzed using ChIP-chip. Table 1 lists the potential targets of Pdr1p with DNA sequences significantly (Z-score>3) and specifically (IP enrichment > mock IP enrichment + 2.5 standard deviations in mock IP measurements) bound by Pdr1p. The complete list of sequences satisfying these criteria is available in supplemental table S4. The ChIP-chip microarray data can be downloaded from www.biologie.ens.fr/lgmgml/publication/fluphe/. The Saccharomyces Genome Database was used to identify the regulated genes from DNA sequences as follows: when intergenic regions (feature name beginning with an “i”) were enriched, the regulated genes were presumed to be the downstream ORFs. In cases of divergent promoters, both ORFs are indicated. Dubious ORFs were considered as intergenic regions (e.g.: YDR010c was assimilated as part of the SNQ2 promoter). The names of genes previously shown to be regulated by Pdr1p are indicated in bold type-face. The type of PDRE present in the sequences is indicated according to (DeRisi et al., 2000). The sensitivity of gene expression to fluphenazine is indicated in the last column. The results obtained for the promoters of RPN4, PDR5, SNQ2 and YGR035c were checked by qPCR (supplemental figure S5).