Six transcriptional regulatory motifs make a significant contribution to the early fluphenazine response



Results of the T-profiler search for DNA motifs significantly induced or repressed by fluphenazine treatment. Only motifs for which a significant change (E-value < 0.05 in T-profiler) was observed over at least two consecutive time points are represented. If several motifs were associated with the same transcription factor, the median t-value of all motifs was used. STRE is the binding motif for Msn2p/Msn4p. PDRE is the binding motif for Pdr1p/Pdr3p. The motif annotated “Crz1” has been identified in the promoters of Crz1p target genes and is different from the traditional CDRE described by (Yoshimoto et al., 2002). PAC, rRNA and rRPE were identified in silico in the promoters of genes repressed in the ESR or involved in rRNA metabolism. The complete results of the T-profiler search are available in supplemental table S2.



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