Presentation

The « Regulation of Genetic Expression » laboratory (UMR 8541) was created by CNRS in 2001 as a continuation of URA 1302 founded in 1989. Today, UMR 8541 comprises 7 independent research teams investigating various properties of genomes from gene expression to DNA replication : structure and evolution of vertebrate genomes (Hugues Roest Crollius) ; the organisation and evolution of gene network in yeast (Claude Jacq) ; the role of RNA helicases in cold-adapted lifestyle (Marc Dreyfus) ; heat shock factors in development (Michel Morange) ; the presence and exchange of the components of the transcriptional machinery on single loci in live-cells (Xavier Darzacq) ; non-coding RNAs regulating transcription efficiency (Olivier Bensaude) ; epigenetic programming of genome rearrangements by non-coding RNAs and RNA interference (Eric Meyer) ; regulation of eukaryotic DNA replication (Olivier Hyrien).

The UMR 8541 is equiped for high performance (speed, 3D spatial resolution and sensitivity) light microscopy. The Department of Biology maintains platforms for functional genomics (DNA chips, RNA profiling), advanced imaging, animal house facilities, mouse gene knock-out and histology.