Randy Poon Mitotic catastrophe : how aberrant mitosis ruins a good genome
Invité par Sylvie Herman-Le Denmat
Le séminaire de Randy Poon aura lieu en salle Favard à partir de 11h.
Mitosis is one of most fundamental processes in cell biology. Although occupying just a fraction of the time of the cell cycle, mitosis is a period particularly prone to irreversible errors. Several mitotic checkpoints ensure that chromosomes are segregated accurately. Genome instability associated with aberrant mitosis is offset by a mechanism termed mitotic catastrophe. Generally defined as a mode of cell death or irreversible growth arrest associated with aberrant mitotic activity, mitotic catastrophe is characterized by an unscheduled activation of cyclin B1–CDK1 and conditions such as precocious entry into mitosis or prolonged mitotic block. While mitotic catastrophe is a key mechanism to prevent genome nstability, it is also being exploited as a strategy for anticancer therapies. Archetypal examples include spindle poisons that disrupt microtubule dynamics and activate the spindle-assembly. Other antimitotic targets including Aurora kinases, Polo-like kinases, and the mitotic kinesin Eg5 are also promising anticancer drug targets.