Département de Biologie

École normale supérieure

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Séminaires du Département de Biologie

  • Mitosis is one of most fundamental processes in cell biology. Although occupying just a fraction of the time of the cell cycle, mitosis is a period particularly prone to irreversible errors. Several mitotic checkpoints ensure that chromosomes are segregated accurately. Genome instability associated with aberrant mitosis is offset by a mechanism termed mitotic catastrophe. Generally defined as a mode of cell death or irreversible growth arrest associated with aberrant mitotic activity, mitotic catastrophe is characterized by an unscheduled activation of cyclin B1–CDK1 and conditions such as precocious entry into mitosis or prolonged mitotic block. While mitotic catastrophe is a key mechanism to prevent genome nstability, it is also being exploited as a strategy for anticancer therapies. Archetypal examples include spindle poisons that disrupt microtubule dynamics and activate the spindle-assembly. Other antimitotic targets including Aurora kinases, Polo-like kinases, and the mitotic kinesin Eg5 are also promising anticancer drug targets.
    vendredi 3 octobre 2014 de 10:30 à 12:00
    Salle Favard
    Randy Poon
    Division of Life Science, HKUST,
    Invité(e) par : Sylvie Hermann-Le Denmat
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Département de Biologie
École Normale Supérieure
46, Rue d’Ulm
75005 Paris
Directeur :
Antoine Triller
Directeur ajdoint :
Patrick Charnay
Secrétariat du département :
Virginie Bues
Secrétariat de l’enseignement :
Anne Zalmanski