Directeur : Antoine Triller
46, Rue d’Ulm, 75005 Paris

Directeur ajdoint : Michel Volovitch
Responsable Enseignements.

Secrétariat :
Béatrice Sissan et Laurence Mancini

Responsable Web :
Alexandre Korber

Programmes

Séminaires du Département de Biologie

Salle P. FAVARD (RC à droite dans le hall)
Département de Biologie - ENS. 46, rue d'Ulm, 75005 Paris

Lundi 15 mars 11:00

En salle P.Favard ENS Paris - Département de Biologie

Frédéric Saudou

Institut Curie
CNRS UMR 146

Invité(e) par Antoine TRILLER,

U789, IBENS.

"Huntingtin and the control of cellular dynamics"

Lundi 29 mars 11:00

En salle P. Favard , ENS - Biologie

Dr. Camilla BELLONE

Dept Neuroscience, Université de Geneve
SUISSE

Invité(e) par Pierre PAOLETTI,

Laboratoire de Neurobiologie CNRS UMR 8544, ENS - Paris.

Tél : 01 44 32 38 94

"Delayed synaptic maturation of glutamatergic transmission in the VTA after in utero cocaine-exposure"

Mardi 30 mars 11:00

En salle P.Favard ENS Paris - IBENS

Prof. Matthias Kneussel

Center for Molecular Neurobiology (ZMNH) University of Hamburg Medical School
Hamburg, Germany

Invité(e) par Antoine TRILLER,

Equipe Biologie de la synapse et regulation de la survie neuronale, ENS-IBENS.

"Activity-regulated cytoskeleton transport of synaptic proteins"

Lundi 12 avril 11:00

En salle P.Favard ENS Paris - Département de Biologie

M. Thomas Papouin

Neurocentre, Magendie
Inserm, Bordeaux

Invité(e) par Pierre PAOLETTI,

Laboratoire de Neurobiologie CNRS UMR 8544, ENS - Paris.

"Of the control of NMDA receptor by its co-agonist site"

Jeudi 29 avril 11:00

En salle P. Favard , ENS Biologie

Michel WERNER

Commissariat à l'Energie Atomique
Saclay

Invité(e) par Olivier BENSAUDE,

Section génomique fonctionnelle, Institut de Biologie - ENS.

Tél : 33 (0)1 4432 3410

"Genome-wide mechanisms of transcription in yeast and mouse"

Lundi 10 mai 11:00

En salle P. Favard , ENS - Biologie

Prof. Stuart CULL-CANDY

University College
London, UK

Invité(e) par Antoine TRILLER,

Laboratoire de Génétique & Neurobiologie de C. elegans - INSERM U 789, ENS - Biologie.

Tél : 01 44 32 35 47

"Calcium permeable AMPA receptors, TARPs and plasticity"

Lundi 17 mai 11:00

En salle P. Favard , ENS - Biologie

Dr. Laurent FAGNI

Departement de Biologie
U789

Invité(e) par Pierre PAOLETTI,

Laboratoire de Neurobiologie Cellulaire & Moléculaire - CNRS UMR 8544, Département de Biologie - ENS - Paris.

Tél : 01-44-32-38-94

"Dynamic Homer-dependent cross-talk between metabotropic and ionotropic glutamate receptors in dendritic spines"

Lundi 31 mai 11:00

En salle P.Favard ENS Paris - Département de Biologie

Zoltan Nusser

Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine
Budapest, Hungary

Invité(e) par Antoine TRILLER,

INSERM U789 , IBENS.

"High-resolution localization reveals unique cell-surface distribution of ion channels"

Lundi 07 juin 11:00

En salle P.Favard ENS Paris - IBENS

Séverine Boillée

Centre de Recherche de l'institut du Cerveau et de la Moelle épinière
Hopital de la Salpêtrière

Invité(e) par Alain BESSIS,

Équipe Neuronal functions and microglia , Institut de Biologie - ENS.

"Microglial contribution to motor neuron degeneration in ALS models"

Jeudi 17 juin 11:00

En salle P.Favard ENS Paris - IBENS

Nathalie Rouach

Collège de France

Invité(e) par Alain BESSIS,

Équipe Neuronal functions and microglia , Institut de Biologie - ENS.

Tél : 01 44 32 35 43

"Connexin 30 controls synaptic strength through astroglial synapse invasion"

Version imprimable

Highlights

  • Eva Coppola, Murielle Rallu, Juliette Richard, Sylvie Dufour, Dieter Riethmacher, François Guillemot, Christo Goridis and Jean-François Brunet

    Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

    doi:10.1073/pnas.0910213107
    Lire la suite...

  • Pierre Paoletti

    FENS EJN Young Investigator Award 2010

    This biennial prize donated by Wiley-Blackwell, publishers of EJN, is given in recognition of outstanding scientific work in all areas of neuroscience.
    Lire la suite...

  • Baudry C, Malinsky S, Restituito M, Kapusta A, Rosa S, Meyer E, Bétermier M

    PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia.

    Genes Dev. 2009 Nov 1 ;23(21):2478-83. PMID : 19884254
    Lire la suite...

  • Gendrel M, Rapti G, Richmond JE, Bessereau JL.

    A secreted complement-control-related protein ensures acetylcholine receptor clustering

    Nature. 2009 Oct 15 ;461(7266):992-6
    Lire la suite...

  • Nomaksteinsky M, Röttinger E, Dufour HD, Chettouh Z, Lowe CJ, Martindale MQ, Brunet JF.

    Centralization of the deuterostome nervous system predates chordates.

    Curr Biol. 2009 Aug 11 ;19(15):1264-9. Epub 2009 Jun 25.
    Lire la suite...

  • Stéphane Le Crom, Wendy Schackwitz, Len Pennacchio, Jon K. Magnuson, David E. Culley, James R. Collett, Joel Martin, Irina S. Druzhinina, Hugues Mathis, Frédéric Monot, Bernhard Seiboth, Barbara Cherry, Michael Rey, Randy Berka, Christian P. Kubicek, Scott E. Bakerd and Antoine Margeot

    Tracking the roots of cellulase hyperproduction by the fungus Trichoderma reesei using massively parallel DNA sequencing

    doi : 10.1073/pnas.0905848106
    Lire la suite...

  • Céline Bidoret, Annick Ayon, Boris Barbour and Mariano Casado

    Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

    doi : 10.1073/pnas.0904284106
    Lire la suite...

  • Hiroko Bannai, Sabine Lévi, Claude Schweizer, Takafumi Inoue, Thomas Launey, Victor Racine, Jean-Baptiste Sibarita, Katsuhiko Mikoshiba and Antoine Triller

    Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics

    DOI 10.1016/j.neuron.2009.04.023
    Lire la suite...

  • Marc Gielen, Beth Siegler Retchless, Laetitia Mony, Jon W. Johnson and Pierre Paoletti

    Mechanism of differential control of NMDA receptor activity by NR2 subunits.

    doi:10.1038/nature07993
    Lire la suite...

  • Felipe Karam Teixeira, Fabiana Heredia, Alexis Sarazin, François Roudier, Martine Boccara, Constance Ciaudo, Corinne Cruaud, Julie Poulain, Maria Berdasco, Mario F. Fraga, Olivier Voinnet, Patrick Wincker, Manel Esteller, Vincent Colot

    A Role for RNAi in the Selective Correction of DNA Methylation Defects

    Science DOI : 10.1126/science.1165313
    Lire la suite...

  • Guillaume P. Dugué, Nicolas Brunel, Vincent Hakim, Eric Schwartz, Mireille Chat, Maxime Lévesque, Richard Courtemanche, Clément Léna and Stéphane Dieudonné.

    Electrical Coupling Mediates Tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network

    DOI 10.1016/j.neuron.2008.11.028
    Lire la suite...

  • Thomas Boulin*, Marc Gielen*, Janet E. Richmond, Daniel C. Williams, Pierre Paoletti and Jean-Louis Bessereau

    Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor

    Lire la suite...

  • Chris Bowler

    Diatom Genome Helps Explain Their Great Diversity and Success in Trapping Excess Carbon in Oceans.

    Lire la suite...

  • Sabine Lévi, Claude Schweizer, Hiroko Bannai, Olivier Pascual, Cécile Charrier, and Antoine Triller

    Homeostatic Regulation of Synaptic GlyR Numbers Driven by Lateral Diffusion

    Antoine Triller and Daniel Choquet

    New Concepts in Synaptic Biology Derived from Single-Molecule Imaging

    Single-molecule approaches give access to the full distribution of molecule behaviors and overcome the averaging intrinsic to bulk measurement methods. They allow access to complex processes where a given molecule can have heterogeneous properties over time. Recent developments in single-molecule imaging technologies have been followed by their wide application in cellular biology and are leading to the unraveling of new mechanisms related to molecular movements. They are shaping new concepts in the dynamic equilibria of complex biological macromolecular assemblies such as synapses. These advances were made possible thanks to improvements in visualization approaches combined with new strategies to label proteins with nanoprobes. In this primer, we will review the different approaches used to track single molecules in live neurons, compare them to bulk measurements, and discuss the different concepts that have emerged from their application to synaptic biology.

    DOI 10.1016/j.neuron.2008.06.022
    Lire la suite...

  • Sayaka Sugiyama, Ariel A. Di Nardo, Shinichi Aizawa, Isao Matsuo, Michel Volovitch, Alain Prochiantz and Takao K. Hensch

    Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity

    DOI 10.1016/j.cell.2008.05.054
    Lire la suite...

  • Camille de Solages, Germán Szapiro, Nicolas Brunel, Vincent Hakim, Philippe Isope, Pierre Buisseret, Charly Rousseau, Boris Barbour et Clément Léna

    High-Frequency Organization and Synchrony of Activity in the Purkinje Cell Layer of the Cerebellum

    Neuron, Vol 58, 775-788, 12 June 2008
    Lire la suite...

  • Gersende Lepère, Mireille Bétermier, Eric Meyer and Sandra Duharcourt

    Maternal noncoding transcripts antagonize the targeting of DNA elimination by scanRNAs in Paramecium tetraurelia.

    Genes & Dev. 2008 22 : 1501-1512. doi:10.1101/gad.473008
    Lire la suite...

  • Pézeron G, Mourrain P, Courty S, Ghislain J, Becker TS, Rosa FM, David NB.

    Live analysis of endodermal layer formation identifies random walk as a novel gastrulation movement.

    Current Biol. 2008 Feb 26 ;18(4):276-81.
    Lire la suite...

  • David Holcman

    ERC-Starting grant

    Modeling cytoplasmic trafficking and molecular delivery in cellular microdomains
    Lire la suite...

  • Olivier Jaillon, Khaled Bouhouche, Jean-François Gout, Jean-Marc Aury, Benjamin Noel, Baptiste Saudemont, Mariusz Nowacki, Vincent Serrano, Betina M. Porcel, Béatrice Ségurens, Anne Le Mouël, Gersende Lepère, Vincent Schächter, Mireille Bétermier, Jean Cohen, Patrick Wincker, Linda Sperling, Laurent Duret & Eric Meyer

    Translational control of intron splicing in eukaryotes

    Nature 451, 359-362 (17 January 2008) | doi:10.1038/nature06495 ; Received 30 September 2007
    Lire la suite...

  • Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J and Paoletti P

    Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition

    Neuron, 2008, 57, 80-93.
    Lire la suite...

  • Sonia Garel

    European Young Investigator Awards (EURYI)

    Wiring the forebrain : roles and mechanisms of tangential cell migration in the basal ganglia
    Lire la suite...

  • Eimer S, Gottschalk A, Hengartner M, Horvitz HR, Richmond J, Schafer WR, Bessereau JL.

    Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.

    The EMBO Journal (2007) 26, 4313–4323
    Lire la suite...

  • Schuss Z, Singer A, Holcman D.

    The narrow escape problem for diffusion in cellular microdomains.

    Proc Natl Acad Sci U S A. 2007 Sep 27.
    Lire la suite...

  • Darzacq X., Shav-Tal Y, de Turis, V. Brody, Y., Shenoy, S.M., Phair, R.D., Singer R.H.

    In Vivo Dynamics of Polymerase II Transcription.

    Nat Struct Mol Biol (In Press doi:10.1038/nsmb1280)
    Lire la suite...

  • Szapiro G, Barbour B.

    Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover.

    Nat Neurosci. 2007, 10:735-42.
    Lire la suite...

  • François SCHWEISGUTH

    Silver medal of CNRS

    Lire la suite...

  • Bouzigues C., Morel M., Triller A.,Dahan M. (Physique and Biology departments)

    Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analyzed by single quantum dot imaging.

    PNAS 2007 104:11251–11256
    Lire la suite...

  • Fontaine C., Dajoz I., Meriguet J., Loreau M.

    Functional Diversity of Plant-Pollinator Interactions Webs Enhances The Percistence of Plant Communities.

    PloS 2006, Vol. 4, Issue 1 e1, pp. 129 135
    Lire la suite...

  • Vardi A, Formiggini F, Casotti R, De Martino A, Ribalet F, et al.

    A stress surveillance system based on calcium and nitric oxide in marine diatoms.

    PLoS Biol. 4(3) : e60.
    Lire la suite...

  • Robert V, Bessereau JL.

    Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks.

    EMBO J. 2007 Jan 10 ;26(1):170-83.
    Lire la suite...

  • Lopez-Bendito*, G., Cautinat*, A., Sanchez, J.A., Bielle, F., Flames, N., Garrat, A.N., Talmage, D., Role, L.W., Charnay, P., Marin*, O. & Garel*, S.

    Neuronal migration opens a path for axons

    Cell, 125 :127-42.
    Lire la suite...